GATA6 monoclonal antibody
Product Specifications
Background
GATA proteins comprise a group of transcription factors that are related by the presence of conserved zinc finger DNA-binding domains, which bind directly to the nucleotide sequence core element GATA . There are six vertebrate GATA proteins, designated GATA-1 to GATA-6 . GATA-6 plays a critical role in endoderm development . It is essential for development of the heart, gut, and other organs . Knock out of GATA-6 is embryonic lethal due to defects in formation of the heart tube and a failure to develop extraembryonic endoderm . Loss of expression, or loss of nuclear localization of GATA-6 is apparent in a large number of ovarian tumors .
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
Transcription factor GATA-6; GATA-binding factor 6
Swiss Prot
Q92908
Reactivity
Human
Immunogen
Purified recombinant human GATA6 protein fragments expressed in E.coli.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of GATA6 protein.
Applications Notes
Western blot analysis of GATA6 expression in Hela (A), Hela (B), 293T (C) whole cell lysates.
Host or Source
Mouse
Available Sizes
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