NRAS Rabbit monoclonal antibody

Product Specifications

Background

The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms . Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway . GTPase-activating proteins (GAPs) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein.

CAS Number

9007-83-4

Structure Composition

Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Product Name Alternative

HRAS1; GTPase NRas; Transforming protein N-Ras

Swiss Prot

P01111

Reactivity

Human, Mouse, Rat, Hamster

Immunogen

A synthetic peptide of human Ras

Conjugation

Unconjugated

Related Pathways

Regulation of Actin Dynamics, Tumor Angiogenesis, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, G Protein-coupled Receptors Signaling to MAPK Erk, MAPK Erk in Growth and Differentiation Pathway, Jak Stat : IL-6 Receptor Signaling, Inhibition of Apoptosis, Insulin &Glucose Signaling, NF-kB Signaling, SAPK JNK Signaling Cascades, T cell receptor signaling, TGFβ Smad signaling, Warburg Effect