GSK3 beta Rabbit monoclonal antibody

Product Specifications

Background

Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β . GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization .

CAS Number

9007-83-4

Structure Composition

Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Product Name Alternative

Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B

Swiss Prot

P49841

Reactivity

Human, Rat, Hamster

Immunogen

A synthetic peptide of human GSK3 beta

Conjugation

Unconjugated

Related Pathways

Adherens Junction signaling, Regulation of Microtubule Dynamics, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, G Protein-coupled, Translational Contral elF4 and p70 S6 Kinase, Translational Contral Regulation of elF2, Receptors Signaling to MAPK Erk, Hedgehog Signaling, Inhibition of Apoptosis, Insulin &Glucose Signaling, NF-kB Signaling, PI3K AKT signaling, Wntβ catenin signaling, MTOR signaling