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GSK3 beta Rabbit monoclonal antibody

Product Specifications

Background

Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β . GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization .

Structure Composition

Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Product Name Alternative

Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B

Swiss Prot

P49841

Reactivity

Human, Rat, Hamster

Immunogen

A synthetic peptide of human GSK3 beta

Conjugation

Unconjugated

Related Pathways

Adherens Junction signaling, Regulation of Microtubule Dynamics, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, G Protein-coupled, Translational Contral elF4 and p70 S6 Kinase, Translational Contral Regulation of elF2, Receptors Signaling to MAPK Erk, Hedgehog Signaling, Inhibition of Apoptosis, Insulin &Glucose Signaling, NF-kB Signaling, PI3K AKT signaling, Wntβ catenin signaling, MTOR signaling

Applications

WB, IHC

Dilution

WB (1/500 - 1/1000), IHC (1/50 - 1/100)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Unmodification

Molecular Weight

~ 46 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of GSK3 beta protein.

Applications Notes

Western blot analysis of GSK3 beta expression in Jurkat (A), C6 (B), CHOK1 (C), Hela (D) whole cell lysates.

Host or Source

Rabbit

CAS Number

9007-83-4

Available Sizes

Curated Selection

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