HO-1 Rabbit monoclonal antibody
Product Specifications
Background
Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme that results in the release of carbon monoxide, iron, and biliverdin. The products of this enzymatic reaction play important biological roles in antioxidant, anti-inflammatory, and cytoprotective functions. HO comprises two isozymes, including the constitutively expressed HO-2 isozyme and the inducible HO-1 isozyme. Inducible HO-1 is expressed as an adaptive response to several stimuli, including heme, metals, and hormones. The induction of HO-1 has been implicated in numerous disease states, such as transplant rejection, hypertension, atherosclerosis, Alzheimer's disease, endotoxic shock, diabetes, inflammation, and neurological disorders.
CAS Number
9007-83-4
Structure Composition
Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.
Product Name Alternative
HO; HO1; Heme oxygenase 1; HO-1
Swiss Prot
P14901/P06762
Reactivity
Mouse
Immunogen
A synthetic peptide of human Heme Oxygenase 1
Conjugation
Unconjugated
Applications
WB, IF/ICC, IP
Dilution
WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 33 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of HO-1 protein.
Applications Notes
Western blot analysis of HO-1 expression in NIH3T3 (A) whole cell lysates.
Host or Source
Rabbit
Available Sizes
Curated Selection
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