CD49e polyclonal antibody

Product Specifications

Background

Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) . Integrin α5/β1 is involved in multiple biological processes including embryonic development, angiogenesis and tumor metastasis. By interaction with its fibronectin ligand, α5/β1 transduces signals that regulate cell adhesion, migration, matrix assembly and cytoskeletal organization.

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e

Swiss Prot

P08648

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein corresponding to human CD49e. The exact sequence is proprietary.

Conjugation

Unconjugated

Related Pathways

Regulation of Actin Dynamics, G Protein-coupled Receptors Signaling to MAPK Erk, MAPK Erk in Growth and Differentiation Pathway, PI3K AKT signaling

Applications

WB, IF/ICC

Dilution

WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Unmodification

Molecular Weight

~ 130 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of CD49e protein.

Applications Notes

Western blot analysis of CD49e expression in NIH3T3 (A), HT1080 (B), rat heart (C) whole cell lysates.

Host or Source

Rabbit

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

sc-61791-SH 20 µg

VILIP-2 shRNA Plasmid (m)

Ask

View Details

FY-AB40994-01 1 mL

FITC-Linked Anti-Neutral Sphingomyelinase (NSMASE)

Ask

View Details

FY-AB40994-02 100 µL

FITC-Linked Anti-Neutral Sphingomyelinase (NSMASE)

Ask

View Details

FY-AB40994-03 200 µL

FITC-Linked Anti-Neutral Sphingomyelinase (NSMASE)

Ask

View Details

MBS1103122-01 0.02 mg (E-Coli)

Recombinant Mycoplasma pneumoniae Uncharacterized protein MG265 homolog (MPN_383)

Ask

View Details

MBS1103122-02 0.02 mg (Yeast)

Recombinant Mycoplasma pneumoniae Uncharacterized protein MG265 homolog (MPN_383)

Ask

View Details