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CD106 polyclonal antibody

Product Specifications

Background

VCAM-1 (vascular cell adhesion molecule-1) is a transmembrane glycoprotein containing multiple amino-terminal extracellular Ig-like domains, a transmembrane domain, and a short carboxy-terminal cytoplasmic domain. Alternative splicing generates two isoforms of VCAM-1. The role of VCAM-1 during infection and inflammatory diseases is well characterized. Expression of VCAM-1 is induced in endothelial cells by inflammatory cytokines including TNF-α and IL-1β. VCAM-1 on endothelial cells interacts with the integrin VLA-4 (α4β1) on leukocytes to mediate migration of circulating leukocytes from the blood across the endothelium and into tissues.

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

L1CAM; Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; INCAM-100; CD106

Swiss Prot

P19320

Reactivity

Human, Mouse, Rat

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD106. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB, IHC, IP

Dilution

WB (1/500 - 1/1000), IHC (1/50 - 1/100), IP (1/50 - 1/100)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Unmodification

Molecular Weight

~ 100 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of CD106 protein.

Applications Notes

Western blot analysis of CD106 expression in rat lung (A) whole cell lysates.

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

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