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Parkin (Phospho-S131) polyclonal antibody

Product Specifications

Background

Arkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box . In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein Parkin.

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

PRKN; E3 ubiquitin-protein ligase parkin; Parkinson juvenile disease protein 2; Parkinson disease protein 2

Swiss Prot

O60260

Reactivity

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Parkin with a phosphorylation site at S131. The exact sequence is proprietary.

Conjugation

Unconjugated

Related Pathways

Dopamine Signaling in Parkinson\'s Disease Plathway

Applications

WB, IHC

Dilution

WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Phosphorylation

Molecular Weight

~ 50 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of Parkin with a phosphorylation site at S131 protein.

Applications Notes

Western blot analysis of Parkin (pS131) expression in SGC7901 (A) whole cell lysates.

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

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