Histone H2B (AcK116) polyclonal antibody
Product Specifications
Background
Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones ore component of nucleosome .Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability .DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling .Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
HIST1H2BA; TSH2B; Histone H2B type 1-A; Histone H2B testis; Testis-specific histone H2B; HIST1H2BB; H2BFF; Histone H2B type 1-B; Histone H2B.1; Histone H2B.f; H2B/f; HIST1H2BC; H2BFL; HIST1H2BE; H2BFH; HIST1H2BF; H2BFG; HIST1H2BG; H2BFA; HIST1H2BI; H2BFK; Histone H2B type 1-C/E/F/G/I; Histone H2B.1 A; Histone H2B.a; H2B/a; Histone H2B.g; H2B/g; Histone H2B.h; H2B/h; Histone H2B.k; H2B/k; Histone H2B.l; H2B/l
Swiss Prot
Q96A08; P33778; P62807
Reactivity
Human, Zebrafish
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Histone H2B with an acetylation site at K116. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 17 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Histone H2B with an acetylation site at K116 protein.
Applications Notes
Western blot analysis of Histone H2B (AcK116) expression in zebrafish (A) whole cell lysates.
Host or Source
Rabbit
Available Sizes
Curated Selection
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