RAB21 (AcK109) polyclonal antibody
Product Specifications
Background
Small GTPase involved in membrane trafficking control.During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis .Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general .As a result, may regulate cell adhesion and migration .Involved in neurite growth .Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion.Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
KIAA0118; Ras-related protein Rab-21
Swiss Prot
Q9UL25
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human RAB21 with a site at AcK109. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 24 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of RAB21 with a site at AcK109 protein.
Applications Notes
Western blot analysis of RAB21 (AcK109) expression in HepG2 (A), Jurkat (B), CT26 (C) whole cell lysates.
Host or Source
Rabbit
Available Sizes
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