RAB21 (AcK109) polyclonal antibody

Product Specifications

Background

Small GTPase involved in membrane trafficking control.During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis .Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general .As a result, may regulate cell adhesion and migration .Involved in neurite growth .Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion.Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 .

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

KIAA0118; Ras-related protein Rab-21

Swiss Prot

Q9UL25

Reactivity

Human, Mouse, Rat

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human RAB21 with a site at AcK109. The exact sequence is proprietary.