Fetuin A polyclonal antibody

Product Specifications

Background

Fetuin A is produced by liver and secreted to plasma, and selectively concentrated in bone matrix. It is synthesized as a precursor and processed to generate 2 chains that are held together by a disulfide bond. It is a systemically acting calcification inhibitor . Reduced level of fetuin A in serum is associated with increased cardiovascular mortality in dialysis patients . Fetuin A can inhibit insulin-induced tyrosine phosphorylation of the insulin receptor tyrosine kinase and insulin receptor substrate-1 . Fetuin A deficient mice show high insulin sensitivity and high levels of serum fetuin A are associated with insulin resistance in humans .

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

FETUA; Alpha-2-HS-glycoprotein; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-A

Swiss Prot

P02765

Reactivity

Human, Mouse, Rat, Bovine, Sheep

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Fetuin A. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

Dilution

WB (1/500 - 1/1000)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Unmodification

Molecular Weight

~ 55 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of Fetuin A protein.

Applications Notes

Western blot analysis of Fetuin A expression in PC12 (A), AML12 (B), HEK293T (C), H1792 (D) whole cell lysates.

Host or Source

Rabbit

Available Sizes

Curated Selection

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