LATS2 polyclonal antibody

Product Specifications

Background

Large tumor suppressor kinase 2 (LATS2) is an AGC kinase of the NDR family of kinases. It is a LATS family tumor suppressor that plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability. LATS2 inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. It also plays an important role in regulation of the Hippo pathway, which is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis.

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

KPM; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase

Swiss Prot

Q9NRM7

Reactivity

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LATS2. The exact sequence is proprietary.

Conjugation

Unconjugated

Related Pathways

Hippo Signaling.

Applications

WB, IHC, IF/ICC

Dilution

WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Unmodification

Molecular Weight

~ 150 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of LATS2 protein.

Applications Notes

Western blot analysis of LATS2 expression in A549 (A), SGC7901 (B) whole cell lysates.

Host or Source

Rabbit

Available Sizes

Curated Selection

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