ACC alpha polyclonal antibody

Product Specifications

Background

Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA . It is the key enzyme in the biosynthesis and oxidation of fatty acids . In rodents, the 265 kDa ACC1 (ACCα) form is primarily expressed in lipogenic tissues, while 280 kDa ACC2 (ACCβ) is the main isoform in oxidative tissues . However, in humans, ACC2 is the predominant isoform in both lipogenic and oxidative tissues . Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC . ACC is a potential target of anti-obesity drugs.

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha

Swiss Prot

Q13085

Reactivity

Human, Mouse, Rat, Bovine, Chicken, Sheep

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ACC alpha. The exact sequence is proprietary.

Conjugation

Unconjugated

Related Pathways

AMPK Signaling Pathway, Warburg Effect.

Applications

WB, IHC

Dilution

WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purity

The antibody was purified by immunogen affinity chromatography.

Modification

Unmodification

Molecular Weight

~ 280 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of ACC alpha protein.

Applications Notes

Western blot analysis of ACC alpha expression in PC12 (A), HEK293T (B), HCT116 (C) whole cell lysates.

Host or Source

Rabbit

Available Sizes

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