Histone H2A (AcK7) polyclonal antibody

Product Specifications

Background

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

CAS Number

9007-83-4

Structure Composition

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

H2AZ; Histone H2A.Z; H2A/z

Swiss Prot

P0C0S5; Q71UI9

Reactivity

Human, Mouse, Rat, Bovine, Sheep

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Histone H2A with a site at AcK7. The exact sequence is proprietary.