Histone H2A (AcK7) polyclonal antibody
Product Specifications
Background
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
H2AZ; Histone H2A.Z; H2A/z
Swiss Prot
P0C0S5; Q71UI9
Reactivity
Human, Mouse, Rat, Bovine, Sheep
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Histone H2A with a site at AcK7. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 14 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Histone H2A with a site at AcK7 protein.
Applications Notes
Western blot analysis of Histone H2A (AcK7) expression in DLD (A), U2OS (B) whole cell lysates.
Host or Source
Rabbit
Available Sizes
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