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Pan Lactic acid-Lysine polyclonal antibody

Product Specifications

Background

Histone lysine lactation (Kla) is a newly discovered histone modification that regulates gene expression in macrophages. In M1 macrophages, lactic acid is derived from incompletely oxidized glucose and then produces lactyl-CoA, which is transferred via acetyltransferase p300 to the lysine tail of the histone. This modification is abundant in gene promoter regions that lack acetylation and are associated with gene expression activation.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence containing crotonylated K.

Conjugation

Unconjugated

Applications

WB

Dilution

WB 1:500 - 1:2000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Histone lysine lactation

Molecular Weight

~ 35-130 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Pan Lactic acid-Lysine polyclonal antibody detects endogenous levels of Pan Lactic acid-Lysine protein.

Applications Notes

Western blot analysis of extracts of various cell lines, using Pan Lactic acid-Lysine antibody at 1:1000 dilution.

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

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