RARγ polyclonal antibody

Nuclear retinoic acid (RA) receptors (RARs) consist of three subtypes encoded by separate genes: α (NR1B1), β (NR1B2), and γ (NR1B3) . For each subtype, there are at least two isoforms, which are generated by differential promoter usage and alternative splicing and differ only in their N-terminal regions. Retinoids, which are metabolites of vitamin A, serve as ligands for RARs. RARs function as ligand-dependent transcriptional regulators and are found to be heterodimerized with retinoid X receptors (RXRs) . These transcriptionally active dimers regulate the expression of genes involved in cellular differentiation, proliferation, and apoptosis. Consequently, RARs play critical roles in a variety of biological processes, including development, reproduction, immunity, and organogenesis. RAR mutations, fusion proteins, altered expression levels, or aberrant post-translational modifications result in multiple diseases due to altered RAR function and disruption of homeostasis.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of RARγ polyclonal antibody at 1:5000 dilution Lane1:A375 whole cell lysate (20ug) Lane2:Hela whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug) Lane4:The Heart tissue lysate of Pig (40ug) Lane5:MCF-7 whole cell lysate (40ug)