IκBα polyclonal antibody
Product Specifications
Background
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
Swiss Prot
P25963
Reactivity
Human, Mouse, Rat, Bovine, Pig, Sheep
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IκBα.
Conjugation
Unconjugated
Applications
WB IHC IF/ICC
Dilution
WB: 1:500~1:1000 IHC: 1:100~1:200 IF/ICC: 1:100~1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
36kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IκBα polyclonal antibody detects endogenous levels of IκBα protein.
Applications Notes
Western blot analysis of IκBα expression in rat kidney (A), rat muscle (B) whole cell lysates.
Host or Source
Rabbit
Available Sizes
Curated Selection
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