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IκBα polyclonal antibody

Product Specifications

Background

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3

Swiss Prot

P25963

Reactivity

Human, Mouse, Rat, Bovine, Pig, Sheep

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IκBα.

Conjugation

Unconjugated

Applications

WB IHC IF/ICC

Dilution

WB: 1:500~1:1000 IHC: 1:100~1:200 IF/ICC: 1:100~1:500

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodified

Molecular Weight

36kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

IκBα polyclonal antibody detects endogenous levels of IκBα protein.

Applications Notes

Western blot analysis of IκBα expression in rat kidney (A), rat muscle (B) whole cell lysates.

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

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