Rad50 polyclonal antibody

Product Specifications

Background

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

RAD50; NBSLD; RAD502; hRad50

Swiss Prot

Q92878

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human Rad50 (NP_005723.2) .

Conjugation

Unconjugated

Applications

WB, IHC, IP

Dilution

WB,1:500 - 1:2000|IHC,1:50 - 1:200|IP,1:20 - 1:50

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .