NBS1/NBN polyclonal antibody
Product Specifications
Background
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
NBN; AT-V1; AT-V2; ATV; NBS; NBS1; P95; nibrin
Swiss Prot
O60934
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NBS1/NBN.
Conjugation
Unconjugated
Applications
WB IF/ICC IHC IP
Dilution
WB,1:500 - 1:1000|IF/ICC,1:100 - 1:500|IP,1:10 - 1:100|IHC,1:100 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 95 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
NBS1/NBN polyclonal antibody detects endogenous levels of NBS1/NBN protein.
Applications Notes
Western blot analysis of Nibrin expression in HEK293T (A), A549 (B), Jurkat (C) whole cell lysates.
Host or Source
Rabbit
Available Sizes
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