JMJD1C polyclonal antibody

Product Specifications

Background

The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

KDM3C; TRIP8; TRIP-8

Swiss Prot

Q15652

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human JMJD1C (NP_116165.1) .

Conjugation

Unconjugated

Applications

WB, IHC

Dilution

WB,1:1000 - 1:2000|IHC,1:50 - 1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .