H2-Aa polyclonal antibody

Enables peptide antigen binding activity. Involved in response to interferon-gamma. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and positive regulation of T cell differentiation. Located in external side of plasma membrane and lysosome. Part of MHC class II protein complex. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog (s) of this gene implicated in several diseases, including autoimmune disease (multiple) ; gastrointestinal system cancer (multiple) ; glomerulonephritis (multiple) ; hematologic cancer (multiple) ; and systemic scleroderma (multiple) . Orthologous to several human genes including HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1) .

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .