H2-Aa polyclonal antibody

Product Specifications

Background

Enables peptide antigen binding activity. Involved in response to interferon-gamma. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and positive regulation of T cell differentiation. Located in external side of plasma membrane and lysosome. Part of MHC class II protein complex. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog (s) of this gene implicated in several diseases, including autoimmune disease (multiple) ; gastrointestinal system cancer (multiple) ; glomerulonephritis (multiple) ; hematologic cancer (multiple) ; and systemic scleroderma (multiple) . Orthologous to several human genes including HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1) .

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha; H2-Aa

Swiss Prot

P14434

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of mouse H2-Aa (NP_034508.2) .

Conjugation

Unconjugated

Applications

Dilution

WB,1:500 - 1:2000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .