CRACR2A polyclonal antibody
Product Specifications
Background
[Isoform 1]: Ca (2+-binding protein that plays a key role in store-operated Ca (2+ entry (SOCE in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca (2+ concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca (2+ resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
CRACR2A; EFCAB4B
Swiss Prot
Q9BSW2
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human CRACR2A (NP_001138430.1) .
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB,1:500 - 1:2000|IHC,1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
45kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Unmodification
Host or Source
Rabbit
Available Sizes
Curated Selection
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