ZNF281 polyclonal antibody

Product Specifications

Background

Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

ZNF281; ZBP-99; ZNP-99

Swiss Prot

Q9Y2X9

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human ZNF281 (NP_036614.1) .

Conjugation

Unconjugated

Applications

WB, IHC

Dilution

WB,1:1000 - 1:3000|IHC,1:50 - 1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .