FADD monoclonal antibody

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis . Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling .

Immunohistochemistry analysis of paraffin-embedded mouse liver using FADD antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.