Acetyl-p53 (Lys370) monoclonal antibody
Product Specifications
Background
Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains.
Structure Composition
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Product Name Alternative
P53; BCC7; LFS1; TRP53
Swiss Prot
P04637
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic acetyl-peptide corresponding to residues surrounding Lys370 of human p53
Conjugation
Unconjugated
Applications
WB, ICC/IF, IP
Dilution
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Purity
Affinity Purified
Modification
Acetylated
Molecular Weight
Calculated MW: 44 kDa; Observed MW: 53 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Immunocytochemistry analysis of Acetyl-p53 in 3T3 using Acetyl-p53 antibody, and DAPI.
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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