Phospho-Presenilin 1 (Ser310) monoclonal antibody
Product Specifications
Background
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) . Requires the other members of the gamma-secretase complex to have a protease activity.
CAS Number
9007-83-4
Structure Composition
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Product Name Alternative
PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182
Swiss Prot
P49768
Reactivity
Human
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser310 of human Presenilin 1
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1/500-1/1000
Purity
Affinity Purified
Modification
Phosphorylated
Molecular Weight
Calculated MW: 53 kDa; Observed MW: 22 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of Phospho-Presenilin 1/PS1 in Jurkat, Hela lysates using Phospho-Presenilin 1 antibody.
Host or Source
Rabbit
Available Sizes
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