FADD polyclonal antibody
Product Specifications
Background
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Product Name Alternative
FADD protein; GIG3; Growth inhibiting gene 3 protein; Mediator of receptor induced toxicity; MORT1
Swiss Prot
Q61160
Reactivity
Mouse
Immunogen
A synthesized peptide derived from mouse FADD
Conjugation
Unconjugated
Applications
WB, IHC-P, FC
Dilution
WB: 1/500-1/1000 IHC: 1/50-1/100 FC: 1/50-1/100
Purity
Affinity Purified
Modification
Unmodified
Molecular Weight
Calculated MW: 23 kDa; Observed MW: 28 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of FADD in Raw264.7 lysates using FADD antibody.
Host or Source
Rabbit
Available Sizes
Curated Selection
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