FOXO4 polyclonal antibody
Product Specifications
Background
The Forkhead family of transcription factors is involved in tumorigenesis of rhabdomyosarcoma and acute leukemias. Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Product Name Alternative
FOXO4; AFX; AFX1; MLLT7; Forkhead box protein O4; Fork head domain transcription factor AFX1
Swiss Prot
P98177
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human FoxO4
Conjugation
Unconjugated
Applications
WB, ICC/IF, IP, FC
Dilution
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100
Purity
Affinity Purified
Modification
Unmodified
Molecular Weight
Calculated MW: 54 kDa; Observed MW: 65 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of FoxO4 in Human heart lysates using FOXO4 antibody.
Host or Source
Rabbit
Available Sizes
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