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Transcription Factor 7 Like 2 polyclonal antibody

Product Specifications

Background

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Product Name Alternative

TCF7L2; HMG box transcription factor 4; HTCF-4; T-cell factor-4 variant X2; T-cell factor 4; Transcription factor 7-like 2; TCF-4

Swiss Prot

Q9NQB0

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human TCF7L2

Conjugation

Unconjugated

Applications

WB, IHC-P, ICC/IF, IP, FC

Dilution

WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100

Purity

Affinity Purified

Modification

Unmodified

Molecular Weight

Calculated MW: 68 kDa; Observed MW: 68 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

IgG

Applications Notes

Western blot analysis of TCF7L2 in Jurkat lysates using Transcription Factor 7 Like 2 antibody.

Host or Source

Rabbit

Available Sizes

Curated Selection

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