DGCR8 polyclonal antibody
Product Specifications
Background
Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs.
Structure Composition
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Product Name Alternative
DGCR8; DGCRK6; Gy1; C22orf12; D16Wis2; pasha
Swiss Prot
Q8WYQ5
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human DGCR8
Conjugation
Unconjugated
Applications
WB, ICC/IF, IP
Dilution
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Purity
Affinity Purified
Modification
Unmodified
Molecular Weight
Calculated MW: 86 kDa; Observed MW: 100 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of DGCR8 in HEK293 lysates; HeLa lysates using DGCR8 antibody.
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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