DGCR8 polyclonal antibody

Product Specifications

Background

Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Product Name Alternative

DGCR8; DGCRK6; Gy1; C22orf12; D16Wis2; pasha

Swiss Prot

Q8WYQ5

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human DGCR8

Conjugation

Unconjugated

Applications

WB, ICC/IF, IP

Dilution

WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Purity

Affinity Purified

Modification

Unmodified

Molecular Weight

Calculated MW: 86 kDa; Observed MW: 100 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

IgG

Applications Notes

Western blot analysis of DGCR8 in HEK293 lysates; HeLa lysates using DGCR8 antibody.

Host or Source

Rabbit

Available Sizes

Curated Selection

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