HEXIM1 polyclonal antibody
Product Specifications
Background
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869) . In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869) . May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550) . Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728) .
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
CLP1; EDG1; HIS1; MAQ1
Swiss Prot
O94992
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230
Conjugation
Unconjugated
Applications
WB, IHC-F, IHC-P, ICC/IF, ELISA
Dilution
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000
Purity
Affinity Purified
Modification
Unmodified
Molecular Weight
Calculated MW: 41 kDa; Observed MW: 41 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of HEXIM1 in rat HEART lysates using HEXIM1 antibody.
Host or Source
Rabbit
Available Sizes
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Lymphotactin (LPTN, LTN, ATAC, C Motif Chemokine 1, Chemokine (C Motif) Ligand 1, Cytokine SCM-1, Lymphotaxin, SCM1, SCM-1, SCM-1-alpha, SCM-1a, Small-inducible Cytokine C1, SCYC1, XC Chemokine Ligand 1, XCL1) (MaxLight 550)
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