LIM Kinase 2 polyclonal antibody
Product Specifications
Background
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042) . Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042) . Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514) . Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403) . Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865) .
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
LIM domain kinase 2
Swiss Prot
P53671
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide of human LIMK2
Conjugation
Unconjugated
Applications
WB, IHC-P, ICC/IF
Dilution
WB: 1/500-1/1000 IHC: 1/50-1/100 ICC: 1/100-1/200
Purity
Affinity Purified
Modification
Unmodified
Molecular Weight
Calculated MW: 72 kDa; Observed MW: 72 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of LIM Kinase 2 in HepG2, HUVEC lysates using LIM Kinase 2 antibody.
Host or Source
Rabbit
Available Sizes
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