Phospho-Leptin Receptor (Tyr1141) polyclonal antibody
Product Specifications
Background
On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) .
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
Leptin receptor; LEP-R; HuB219 OB receptor; OB-R; CD295; LEPR; DB; OBR
Swiss Prot
P48357
Reactivity
Human, Mouse
Immunogen
Synthetic peptide of human LEPR
Conjugation
Unconjugated
Applications
WB, ELISA
Dilution
WB: 1/500-1/1000 ELISA: 1/10000
Purity
Affinity Purified
Modification
Phosphorylated
Molecular Weight
Calculated MW: 132 kDa; Observed MW: 132 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of Phospho-Leptin Receptor in K562 lysates using Phospho-Leptin Receptor antibody.
Host or Source
Rabbit
Available Sizes
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