Phospho-HDAC6 (Ser22) polyclonal antibody
Product Specifications
Background
Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
Swiss Prot
Q9UBN7
Reactivity
Human, Mouse
Immunogen
Synthetic peptide of human HDAC6
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1/500-1/1000
Purity
Affinity Purified
Modification
Phosphorylated
Molecular Weight
Calculated MW: 131 kDa; Observed MW: 131 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of Phospho-HDAC6 in 3T3 lysates using Phospho-HDAC6 antibody.
Host or Source
Rabbit
Available Sizes
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