Phospho-4E BP1 (Thr70) polyclonal antibody
Product Specifications
Background
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
Swiss Prot
Q13541
Reactivity
Human
Immunogen
Synthetic peptide of human EIF4EBP1
Conjugation
Unconjugated
Applications
IHC-P
Dilution
IHC: 1/50-1/100
Purity
Affinity Purified
Modification
Phosphorylated
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma tissue using Phospho-4E BP1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Sample with blocking peptide on the right.
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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