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IDO 2 polyclonal antibody

Product Specifications

Background

INDOL1 is also known as IDO2 (indoleamine 2,3-dioxygenase 2) and is a 407 amino acid protein that is expressed in various tissues, including liver, small inTine, spleen, placenta, thymus, lung, brain, kidney, colon and dendritic cells. INDOL1 is selectively inhibited by D-1MT (1-methyl-d-tryptophan), which also inhibits IDO (indoleamine 2,3-dioxygenase) and is significant because IDO expression causes suppression of T cell responses to tumors in dendritic cells. The inhibition of INDOL1 by D-1MT suggests a common function in immunomodulation. In the human INDOL1 gene, two single nucleotide polymorphisms have been detected which abolish the enzymatic function of INDOL1.

CAS Number

9007-83-4

Structure Composition

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Product Name Alternative

IDO2; INDOL1; Indoleamine 2; 3-dioxygenase 2; IDO-2; Indoleamine 2; 3-dioxygenase-like protein 1; Indoleamine-pyrrole 2; 3-dioxygenase-like protein 1

Swiss Prot

Q6ZQW0

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human IDO2. AA range:101-150

Conjugation

Unconjugated

Applications

WB, ELISA

Dilution

WB: 1/500-1/1000 ELISA: 1/10000

Purity

Affinity Purified

Modification

Unmodified

Molecular Weight

Calculated MW: 47 kDa; Observed MW: 47 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

IgG

Applications Notes

Western blot analysis of IDO 2 in HeLa, HepG2 lysates using IDO 2 antibody.

Host or Source

Rabbit

Available Sizes

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