EYA1/4 polyclonal antibody

Product Specifications

Background

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity) . Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.

CAS Number

9007-83-4

Structure Composition

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Product Name Alternative

Eyes absent homolog 1; Eyes absent homolog 4

Swiss Prot

Q99502/O95677

Reactivity

Human, Mouse

Immunogen

Synthetic peptide from human protein at AA range: 271-320

Conjugation

Unconjugated

Applications

IHC-P, ELISA

Dilution

IHC: 1/50-1/100 ELISA: 1/10000

Purity

Affinity Purified

Modification

Unmodified

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

IgG

Applications Notes

Immunohistochemistry analysis of paraffin-embedded Human kidney using EYA1/4 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.