JAK2 (7H5) monoclonal antibody
Product Specifications
Background
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
Swiss Prot
O60674
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide conjugated to KLH.
Conjugation
Unconjugated
Applications
IHC-P
Dilution
IHC: 1/50-1/100
Purity
Affinity Purified
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG1
Applications Notes
Immunohistochemistry analysis of paraffin-embedded Human Lung Carcinoma Tissue using JAK2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Host or Source
Mouse
Available Sizes
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