Phospho-ERK1/2 (Tyr222/Tyr205) (10C8) monoclonal antibody
Product Specifications
Background
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
MAPK1/MAPK3
Swiss Prot
P27361/P28482
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide conjugated to KLH.
Conjugation
Unconjugated
Applications
IHC-P
Dilution
IHC: 1/50-1/100
Purity
Affinity Purified
Modification
Phosphorylated
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG1
Applications Notes
Immunohistochemistry analysis of paraffin-embedded Human Colon Carcinoma Tissue using Phospho-ERK1/2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Host or Source
Mouse
Available Sizes
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