MLKL (5E3) monoclonal antibody

Product Specifications

Background

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

CAS Number

9007-83-4

Structure Composition

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Product Name Alternative

MLKL

Swiss Prot

Q8NB16

Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH.

Conjugation

Unconjugated

Applications

IHC-P

Dilution

IHC: 1/50-1/100

Purity

Affinity Purified

Modification

Unmodified

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

IgG1

Applications Notes

Immunohistochemistry analysis of paraffin-embedded Human Tonsil Tissue using MLKL antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.