BMP2K polyclonal antibody
Product Specifications
Background
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BMP2K (BMP2 inducible kinase), also known as BIKE, is a 1,161 amino acid nuclear protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Thought to be involved in osteoblast differentiation, BMP2K catalyzes the ATP-dependent phosphorylation of bone morphogenic proteins (BMPs) ; proteins that are essential for proper cartilage and bone formation. Via its catalytic activity, BMP2K may play a role in signaling pathways that mediate bone growth and cellular differentiation. Three isoforms of BMP2K exist due to alternative splicing events.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
BMP-2-inducible protein kinase; BIKe; BMP2K; BIKE; HRIHFB2017
Swiss Prot
Q9NSY1
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to Human BMP2K.
Conjugation
Unconjugated
Applications
WB IP
Dilution
WB: 1:1000~1:2000 IP 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 130 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
BMP2K polyclonal antibody detects endogenous levels of BMP2K protein.
Applications Notes
Western blot (WB) analysis of BMP2K polyclonal antibody at 1:1000 dilution Lane1:A549 whole cell lysate (30ug) Lane2:MCF-7 whole cell lysate (30ug)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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