CD112/NECTIN2 polyclonal antibody

Product Specifications

Background

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive .Probable cell adhesion protein .

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Product Name Alternative

Nectin-2; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2; CD112

Swiss Prot

Q92692

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CD112/NECTIN2.

Conjugation

Unconjugated

Applications

WB IF

Dilution

WB: 1:2000~1:5000 IF 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodified

Molecular Weight

~ 60-70 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

CD112/NECTIN2 polyclonal antibody detects endogenous levels of CD112/NECTIN2 protein.

Applications Notes

Western blot (WB) analysis of CD112/NECTIN2 polyclonal antibody at 1:2000 dilution Lane1:CT-26 whole cell lysate (30ug) Lane2:H1792 whole cell lysate (20ug) Lane3:HEK293T whole cell lysate (20ug)