SUFU polyclonal antibody
Product Specifications
Background
Su (fu) (for Suppressor-of-Fused) is a key negative regulator in the vertebrate Hedgehog signaling pathway. Su (fu) interacts with genes encoding proteins in this signal transduction pathway. In Drosophila, Intracellular transduction of the Hedgehog pathway involves the release of a large complex containing Su (fu) . Su (fu) inhibits the activity of the transcription factor Gli1 and interacts with Gli2, Gli3 and the serine/threonine kinase Fused. Su (fu) is widely expressed in adult and embryonic tissues with higher expression in tissues patterned by hegdehog signaling. The Su (fu) gene locus maps to a region that is deleted in glioblastomas, prostate cancer, malignant melanoma and endometrial cancer.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Suppressor of fused homolog; SUFUH; SUFU; UNQ650; PRO1280
Swiss Prot
Q9UMX1
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 325-484 of human SUFU (NP_057253.2) .
Conjugation
Unconjugated
Applications
WB IHC-P IF/ICC
Dilution
WB: 1:500~1:2000 IHC-P/IF/ICC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 54 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SUFU polyclonal antibody detects endogenous levels of SUFU protein.
Applications Notes
Western blot analysis of various lysates, using SUFU pAb at 1:1000 dilution.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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