TRPC6 polyclonal antibody
Product Specifications
Background
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
TRP6; FSGS2
Swiss Prot
Q9Y210
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human TRPC6 (NP_004612.2) .
Conjugation
Unconjugated
Applications
WB IHC-P
Dilution
WB: 1:500-1:1000 IHC-P: 1:50-1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 106 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TRPC6 polyclonal antibody detects endogenous levels of TRPC6 protein.
Applications Notes
Western blot analysis of extracts of Mouse pancreas, using TRPC6 antibody at 1:1000 dilution.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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