SHC Rabbit monoclonal antibody
Product Specifications
Background
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
SH2 domain protein C1; SHC; SHC-transforming protein 1; SHCA; Src homology 2 domain-containing-transforming protein C1
Swiss Prot
P29353
Reactivity
Human Mouse Rat
Immunogen
A synthesized peptide derived from human SHC
Conjugation
Unconjugated
Applications
WB IHC ICC/IF FC
Dilution
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50
Purity
Affinity-chromatography
Modification
Unmodified
Molecular Weight
46, 52, 66kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SHC Antibody detects endogenous levels of total SHC
Applications Notes
Western blot analysis of SHC expression in MCF7 cell lysate.
Host or Source
Rabbit
Available Sizes
Curated Selection
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