PHD2 / prolyl hydroxylase Rabbit monoclonal antibody
Product Specifications
Background
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
EGLN1; C1orf12; ECYT3; HIFPH2; HPH2; PHD2; SM-20; SM20; ZMYND6
Swiss Prot
Q9GZT9
Reactivity
Human
Immunogen
A synthesized peptide derived from human PHD2 / prolyl hydroxylase
Conjugation
Unconjugated
Applications
WB IP
Dilution
WB 1:500~1:2000 IP 1:50
Purity
Affinity-chromatography
Modification
Unmodified
Molecular Weight
46kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PHD2 / prolyl hydroxylase Antibody detects endogenous levels of total PHD2 / prolyl hydroxylase
Applications Notes
Western blot analysis of PHD2 / prolyl hydroxylase expression in SH-SY5Y cell lysate.
Host or Source
Rabbit
Available Sizes
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