Granzyme B Rabbit monoclonal antibody
Product Specifications
Background
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Granzyme B; Cathepsin G-like 1; CTSGL1; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; SECT; GZMB; CGL1; CSPB; CTLA1, GRB
Swiss Prot
P10144
Reactivity
Human
Immunogen
A synthesized peptide derived from human Granzyme B
Conjugation
Unconjugated
Applications
IHC ICC/IF IP
Dilution
IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50
Purity
Affinity-chromatography
Modification
Unmodified
Molecular Weight
38kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Granzyme B Antibody detects endogenous levels of total Granzyme B
Host or Source
Rabbit
Available Sizes
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