Phospho-AKT1 (S124) Rabbit monoclonal antibody

Product Specifications

Background

Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Product Name Alternative

AKT 1; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha

Swiss Prot

P31749

Reactivity

Human Mouse Rat

Immunogen

A synthesized peptide derived from human AKT1

Conjugation

Unconjugated

Applications

WB IP

Dilution

WB 1:500~1:1000 IP 1:50

Purity

Affinity-chromatography

Modification

Phosphorylated

Molecular Weight

60kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Phospho-AKT1 (S124) Antibody detects endogenous levels of Phospho-AKT1 (S124)

Applications Notes

Western blot analysis of Phospho-AKT1 (S124) expression in (1) MCF-7 cell treated with Alkaline Phosphatase lysate; (2) MCF-7 cell lysate.

Host or Source

Rabbit

Available Sizes

Curated Selection

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